Cause and consequence of DNA damage in cancer
DNA damage has a significant impact on the state of cells by creating genetic changes that lead to aberrant gene expression. Double-strand DNA breaks are primarily repaired by the high fidelity homologous recombination repair (HRR) mechanism. A deficiency in HR (HRD) leads to error-prone repair mechanisms like Non-homologous end joining. recently, PARP inhibitors have emerged as potent therapeutic drugs in tumors with HRD.
This project aims to study the functional relevance of mutations in BRCAness genes concerning the homologous recombination deficiency and sensitivity to platinum therapy.