{"id":96,"date":"2022-02-08T14:27:01","date_gmt":"2022-02-08T14:27:01","guid":{"rendered":"https:\/\/dga.medunigraz.at\/wp\/?page_id=96"},"modified":"2025-04-11T17:29:32","modified_gmt":"2025-04-11T15:29:32","slug":"projects","status":"publish","type":"page","link":"https:\/\/dga.medunigraz.at\/wp\/?page_id=96","title":{"rendered":"Projects"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"cause-and-consequence-of-dna-damage-in-cancer\">Cause and consequence of DNA damage in cancer<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"has-text-align-left\">DNA damage has a significant impact on the state of cells by creating genetic changes that lead to aberrant gene expression. Double-strand DNA breaks are primarily repaired by the high fidelity homologous recombination repair (HRR) mechanism. A deficiency in HR (HRD) leads to error-prone repair mechanisms like Non-homologous end joining. recently, PARP inhibitors have emerged as potent therapeutic drugs in tumors with HRD. <\/p>\n\n\n\n<div style=\"height:5px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>This project aims to study the functional relevance of mutations in BRCAness genes concerning the homologous recombination deficiency and sensitivity to platinum therapy. <\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-space-between is-layout-flex wp-container-core-buttons-is-layout-3d213aab wp-block-buttons-is-layout-flex\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-css-opacity has-background is-style-dots\" style=\"background-color:#c7c6b3;color:#c7c6b3\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"genetic-events-in-the-progression-from-precancerous-lesions-to-invasive-carcinoma\">Genetic events in the progression from precancerous lesions to invasive carcinoma <\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\"><\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cause and consequence of DNA damage in cancer DNA damage has a significant impact on the state of cells by creating genetic changes that lead to aberrant gene expression. Double-strand DNA breaks are primarily repaired by the high fidelity homologous recombination repair (HRR) mechanism. A deficiency in HR (HRD) leads to error-prone repair mechanisms like&#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-96","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/dga.medunigraz.at\/wp\/index.php?rest_route=\/wp\/v2\/pages\/96","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dga.medunigraz.at\/wp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dga.medunigraz.at\/wp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dga.medunigraz.at\/wp\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/dga.medunigraz.at\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=96"}],"version-history":[{"count":28,"href":"https:\/\/dga.medunigraz.at\/wp\/index.php?rest_route=\/wp\/v2\/pages\/96\/revisions"}],"predecessor-version":[{"id":367,"href":"https:\/\/dga.medunigraz.at\/wp\/index.php?rest_route=\/wp\/v2\/pages\/96\/revisions\/367"}],"wp:attachment":[{"href":"https:\/\/dga.medunigraz.at\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=96"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}